The tradition of care at The Wesley Hospital dates back to 1896 when Dr Charles Kebbell converted a humble building situated on Brisbane’s south bank into a private hospital. In 1901, the hospital was purchased by Dr Ernest Sandford Jackson, a pioneer surgeon in Queensland, and he named it St Helen's Hospital.
Dr Sandford Jackson invited many prominent Brisbane surgeons of the time to use the hospital's facilities to treat their patients. The scope of activities and the hospital's reputation for outstanding medical and nursing care developed significantly after 1949 when it was purchased by the Methodist Church and rebuilt. The State Government’s plans for the redevelopment of the South Brisbane region prompted a move to Moorlands Estate at Auchenflower, where a new hospital, The Wesley Hospital, was established and opened on 1 March 1977. The first patients in the new Wesley Hospital were transferred from the former St Helen's Methodist Hospital. With the union of the Presbyterian, Methodist and Congregational Churches in 1977, the Wesley became, and remains, an activity of the Uniting Church.
Today, the Wesley is one of Queensland's largest private hospitals and has the most comprehensive range of private medical services in Australia. With more than 500 beds, the hospital has grown in response to emerging trends in the delivery of private healthcare and the growing population of South East Queensland.